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July 8, 2008 by jayakumar2898New group of stem cells found
June 24, 2008 by jayakumar2898Researchers in the United States have discovered a new group of stem cells that can give rise to heart muscle cells, known as cardiomyocytes, according to a study published on Sunday. The stem cells are located in the outermost layer of the heart and could one day play a critical role in regenerating injured heart tissue, the researchers say.
“In heart failure, you lose cardiomyocytes, so the only way to reverse heart failure is to make more of these cells.” Said William Pu, the study’s lead researcher and a paediatric cardiologist at the Children’s Hospital in Boston, Massachusetts. The new findings come on the heels of two earlier break throughs.
In 2006, scientists identified another cardiac stem cell – marked by the expression of a gene called Nkx2-5 – with the potential to become lining blood muscle or cells lining blood vessels in the organ’s left-sided chambers.
Key role of stem cells
Gene expression is the process by which information encoded in the DNA of a particular gene is transformed into a protein or RNA, which plays a key role in protein synthesis. In parallel, other U.S. researchers discovered a related progenitor heart cell – so-called because of its capacity to generate different types of tissue – that produces the same cell types in the right sided heart chambers.
Mr.Pu’s study, published online in the journal Nature, shows for the first time that new heart stem cells can also be derived from a third type of cardiac stem cell, located within the surface of the organ and identifiable through its expression of a gene called Wtl.
The results were independently verified by another team of scientists at the University of California in San Diego, whose research was published in the same issue of Nature. Mr.pu and his colleagues showed that the cells from the heart’s outer lining, called the epicardium, can not only metamorphose into cardiomyocytes but also into smooth muscle cells, endothelial cells, which line the interior of blood vessels, and fibroblasts, found in connective tissue.
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